Results 171 to 180 of about 5,793,293 (269)

Implementation of a Model-Based Design in a Phase Ib Study of Combined Targeted Agents. [PDF]

Clin Cancer Res, 2017
Wages NA, Portell CA, Williams ME, Conaway MR, Petroni GR.   +4 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Enabling Model-Based Design for Real-Time Spike Detection. [PDF]

IEEE Open J Eng Med Biol
Di Florio M, Bornat Y, Care M, Rosa Cota V, Buccelli S, Chiappalone M.   +5 more
europepmc   +1 more source

Model-Based Design of Biochemical Microreactors. [PDF]

Front Bioeng Biotechnol, 2016
Elbinger T, Gahn M, Neuss-Radu M, Hante FM, Voll LM, Leugering G, Knabner P.   +6 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Model-based design of a mechanically intelligent shape-morphing structure. [PDF]

Sci Rep
Chen Q, Schott D, Jovanova J.
europepmc   +1 more source

Model-based design of RNA hybridization networks implemented in living cells. [PDF]

Nucleic Acids Res, 2017
Rodrigo G, Prakash S, Shen S, Majer E, Daròs JA, Jaramillo A.   +5 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A novel model of learning in design

, 2001
Learning in design is a phenomenon that has been observed in design practice by many researchers. The observation that designers learn is supported by protocol studies in design that experienced designers can reach satisfactory design solutions more ...
Duffy, Alex H.B., Sim, Siang Kok
core  

Model-based design of a pneumatic actuator for a dynamically reconfigurable socket for transtibial amputees. [PDF]

Front Bioeng Biotechnol
Mollaee S, HajiRassouliha A, Budgett DM, Taberner AJ, Nielsen PMF.   +4 more
europepmc   +1 more source