Results 181 to 190 of about 5,793,293 (269)

Model-Based Design of Tree WSNs for Decentralized Detection. [PDF]

Sensors (Basel), 2015
Tantawy A, Koutsoukos X, Biswas G.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Exploring future use: scenario based design

, 2013
The future use of products and services will be determined by both their design and the different ways in which they are used. It is difficult to understand and to explore this future use as it is hard to imagine and predict something that is not ...
van der Bijl-Brouwer, M, van der Voort, MC   +1 more
core  

Self-optimisation and model-based design of experiments for developing a C-H activation flow process. [PDF]

Beilstein J Org Chem, 2017
Echtermeyer A, Amar Y, Zakrzewski J, Lapkin A.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Efficient Optimization of Stimuli for Model-Based Design of Experiments to Resolve Dynamical Uncertainty. [PDF]

PLoS Comput Biol, 2015
Mdluli T, Buzzard GT, Rundell AE.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Investigation of a Design Performance Measurement Tool for improving collaborative design during a design process

, 2009
With rapid growth of global competition, the design process is becoming more and more complex due largely to cross-functional team collaboration, dynamic design processes, and unpredictable design outcomes.
Yin, Yuanyuan
core  

Model-Based Design of Experiments for Temporal Analysis of Products (TAP): A Simulated Case Study in Oxidative Propane Dehydrogenation. [PDF]

Ind Eng Chem Res
Yonge A, Gusmão GS, Fushimi R, Medford AJ.   +3 more
europepmc   +1 more source

Structure guided homology model based design and engineering of mouse antibodies for humanization. [PDF]

Bioinformation, 2014
Kurella VB, Gali R.
europepmc   +1 more source