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Model-Based Methods in the Biopharmaceutical Process Lifecycle. [PDF]
Model-based methods are increasingly used in all areas of biopharmaceutical process technology. They can be applied in the field of experimental design, process characterization, process design, monitoring and control. Benefits of these methods are lower experimental effort, process transparency, clear rationality behind decisions and increased process
Kroll P +4 more
europepmc +4 more sources
Keynote lecture. Towards reliability-management for debris flow risk assessment [PDF]
Recent progress in data-integrated simulation methods excelled our understanding of debris flows including triggering mechanisms and dynamic run-out behavior.
Kowalski Julia, Zhao Hu, Yildiz Anil
doaj +1 more source
Elements of future snowpack modeling – Part 2: A modular and extendable Eulerian–Lagrangian numerical scheme for coupled transport, phase changes and settling processes [PDF]
A coupled treatment of transport processes, phase changes and mechanical settling is the core of any detailed snowpack model. A key concept underlying the majority of these models is the notion of layers as deforming material elements that carry the ...
A. Simson +4 more
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Global, high-resolution mapping of tropospheric ozone – explainable machine learning and impact of uncertainties [PDF]
Tropospheric ozone is a toxic greenhouse gas with a highly variable spatial distribution which is challenging to map on a global scale. Here, we present a data-driven ozone-mapping workflow generating a transparent and reliable product.
C. Betancourt +9 more
doaj +1 more source
Response inhibition and interference resolution are often considered subcomponents of an overarching inhibition system that utilizes the so-called cortico-basal-ganglia loop.
S.J.S. Isherwood +13 more
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With the booming of worldwide agriculture intensification, brucellosis, one of the most neglected zoonotic diseases, has become an increasing challenge for global public health.
Cuihong An +12 more
doaj +1 more source
Fault Detection and Diagnosis Encyclopedia for Building Systems: A Systematic Review
This review aims to provide an up-to-date, comprehensive, and systematic summary of fault detection and diagnosis (FDD) in building systems. The latter was performed through a defined systematic methodology with the final selection of 221 studies.
Simon P. Melgaard +4 more
doaj +1 more source
Maintenance is crucial for aircraft engines because of the demanding conditions to which they are exposed during operation. A proper maintenance plan is essential for ensuring safe flights and prolonging the life of the engines.
Maria Grazia De Giorgi +2 more
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Applications of predictive maintenance techniques in industrial systems [PDF]
Prognostic methods represent a new methodology for system maintenance which offers significant time and cost savings. The paper offers a short overview of the available prognosis techniques and proposes the implementation of one model-based and ...
Marjanović Aleksandra +3 more
doaj +1 more source
Approaches for diagnosis and prognosis of the health of engineering systems are divided into data-driven, model-based, and hybrid methods. Data-driven methods depend on the availability of data.
Simon Hagmeyer, Peter Zeiler
doaj +1 more source

