Results 81 to 90 of about 784,487 (340)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A multilevel integrative approach to hospital case mix and capacity planning. [PDF]

Hospital case mix and capacity planning involves the decision making both on patient volumes that can be taken care of at a hospital and on resource requirements and capacity management.
Demeulemeester, Erik, Ma, Guoxuan
core  

EVALUATION OF SOME PRODUCTION CHARACTERISTICS OF RECURSIVE CONVEYOR

Открытое образование (Москва), 2016
We consider the two objectives of direct relevance to operational planning based on the model of recursive conveyor process. Calculate the Critical Operation of the conveyor and calculate the Load Factor of the equipment of the conveyor.
Boris V. Kupriyanov
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A problem-structuring model for analyzing transportation–environment relationships

, 2010
This is the post-print version of the final paper published in European Journal of Operational Research. The published article is available from the link below.
Özgür Kabak, Ülengin, F, Kabak, Özgür, Ülengin, B, Şule Önsel, Burç Ülengin, Emel Aktaş, Önsel Ekici, Şule, Ülengin, Burç, Aktaş, Emel, Aktaş, E, Ülengin, Füsun, Önsel, S, Kabak, Ö, Onsel, Sule, Füsun Ülengin   +15 more
core   +1 more source

On the identification of sales forecasting models in the presence of promotions [PDF]

, 2014
Shorter product life cycles and aggressive marketing, among other factors, have increased the complexity of sales forecasting. Forecasts are often produced using a Forecasting Support System that integrates univariate statistical forecasting with ...
Trapero, Juan R., Kourentzes, Nikos, Trapero, Juan R.,, Kourentzes, Nikolaos,, Fildes, Robert, Fildes, Robert,   +5 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A Windowed Transportation Planning Model [PDF]

This research develops and applies a transportation planning model that integrates regional and local area forecasting approaches. While regional models have the scope to model the interaction of demand and congestion, they lack the spatial detail of a ...
Yuanlin Huang, David Levinson
core  

Integrating multicriteria decision analysis and scenario planning : review and extension [PDF]

, 2013
Scenario planning and multiple criteria decision analysis (MCDA) are two key management science tools used in strategic planning. In this paper, we explore the integration of these two approaches in a coherent manner, recognizing that each adds value to ...
French, Simon, Rios, Jesus, Stewart, Theodor J.   +2 more
core   +1 more source

Modellbasierte Kostenermittlung/Model-based cost calculation – Extension of DIN 276 to factories in planning, execution, and operation

wt Werkstattstechnik online
Der Beitrag erweitert die DIN 276 um Fabrikelemente sowie Betriebskosten, um eine ganzheitliche Kostenermittlung über den gesamten Lebenszyklus einer Fabrik zu erlauben. Durch die Integration von VDI 5200–4 und VDI 2067–1 entsteht eine konsistente Grundlage für modellbasierte, BIM-gestützte Kostenermittlungen.
Thomas Neuhäuser, Christian Johannes Eckart, Julian Hartwich-Fischer, Franziska Wagner, Tobias Huber, Sven Forte   +5 more
openaire   +1 more source