Results 171 to 180 of about 45,910,073 (298)

A Copula-based framework for seismic resilience assessment of civil engineering structural systems. [PDF]

MethodsX
Xie C, Xu S, Zheng Q, Liu Y, Zhou J, Li J, Zhang K, Zhang W.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Stochastic dynamic programming for condition-based maintenance and production considering predetermined demand and maintenance delay in a finite planning horizon. [PDF]

PLoS One
Mohammadipour P, Farughi H, Rasay H.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Hybrid computational intelligence framework for accurate wind power forecasting and grid integration applications. [PDF]

Sci Rep
Alkhrissat T, Abed FB, Aldulaimi S, Chohan JS, Ranganathaswamy MK, Pradhan P, Mamadiyarov Z, Nurmatovich HA.   +7 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Approach for model-based test specifications in the context of space engineering

The increasing complexity and interdisciplinarity of space projects re-quire a formalization and digitalization of the development process. Model-based Systems Engineering offers an approach to formally capture the systems engi-neering methodology and ...
Brahm, Michael, Krause, Dieter, Berschik, Markus Christian, Inselmann, Pascal   +3 more
core   +1 more source

Comment on "Development and External Validation of a Machine Learning-Based System for Predicting 4-Year Incident Sarcopenia in Multimorbid Older Adults: Results From Two Prospective Cohorts". [PDF]

Geriatr Gerontol Int
Madbushi S, Pokharkar ST, Golhar Y.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

An asymptotic slender-body model for predicting print resolution in extrusion-based bioprinting. [PDF]

J Eng Math
Tansell AV, Luo GJ, Diakourti P, Mahmoodi N, Thomas-Seale LEJ, Dyson RJ.   +5 more
europepmc   +1 more source