Results 191 to 200 of about 4,021,533 (345)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

An optimized ensemble framework for machinery fault detection in IoT environments. [PDF]

Sci Rep
Devi Gayadri SV, Kanagaraj G, Giri J, Kanan M.   +3 more
europepmc   +1 more source

Teaming System Engineers, AI Agents, and tools for Model-Based System Engineering

Ramon Conejo, Éric Jenn, Jean-Marie Gauthier, Emilie Perreau   +3 more
openalex   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Deformation control equations for engineering piles subjected to vertical and nonlinear lateral loads. [PDF]

Sci Rep
Chen B, Lian N, Dai P, Wang Z, Su T.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Robotic cell transportation system based on micropipette resistance modeling. [PDF]

Microsyst Nanoeng
Zhao Q, Liu M, Zhu R, Qiu J, Fu S, Li R, Zhao X.   +6 more
europepmc   +1 more source

Al2O3 and γAl2O3 Nanomaterials based Nanofluid Models with Surface Diffusion: Applications for Thermal Performance in Multiple Engineering Systems and Industries

, 2020
Adnan Abbasi, Umar Khan, Naveed Ahmed, Syed Tauseef Mohyud‐Din, Ilyas Khan, Dumitru Bǎleanu, Kottakkaran Sooppy Nisar   +6 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Developing a Thermal Design Optimization Method Based on the Model of SGE – System Generation Engineering

Simon Knecht, Michael Schlegel, Christoph Kempf, Albert Albers   +3 more
openalex   +2 more sources