Results 111 to 120 of about 4,420,277 (273)

How to fit models of recognition memory data using maximum likelihood.

International Journal of Psychological Research, 2010
The aim of this paper is to provide an introductory tutorial to how to fit different models of recognition memory using maximum likelihood estimation. It is in four main parts.
John C. Dunn
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Three New Studies on Model-data Fit for Latent Variable Models in Educational Measurement

, 2019
This dissertation encompasses three studies on issues of model-data fit methods for latent variable models implemented in modern educational measurement. The first study proposes a new statistic to test the mean-difference of the ability distributions estimated based on the responses of a group of examinees, which can be used to detect aberrant ...
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Psychometric Evaluation of the Assessment of the Burden of COPD Scale According to the Rasch Model

COPD
To facilitate shared decision-making in Chronic obstructive pulmonary disease (COPD), the Assessment of the Burden of COPD (ABC) tool was developed. An integral part of the ABC tool is the ABC scale, a questionnaire to determine COPD burden.
Maarten Voorhaar, Antoine Regnault, Onno C. P. van Schayck, Jean Muris, Annerika H. M. Slok   +4 more
doaj   +1 more source

Application Mail Tracking Using RSA Algorithm As Security Data and HOT-Fit a Model for Evaluation System

E3S Web of Conferences, 2018
RSA algorithm give security in the process of the sending of messages or data by using 2 key, namely private key and public key .In this research to ensure and assess directly systems are made have meet goals or desire using a comprehensive evaluation ...
Setyo Permadi Ginanjar, Adi Kusworo, Gernowo Rahmad   +2 more
doaj   +1 more source

The Augmented Synthetic Control Method

, 2020
The synthetic control method (SCM) is a popular approach for estimating the impact of a treatment on a single unit in panel data settings. The "synthetic control" is a weighted average of control units that balances the treated unit's pre-treatment ...
Ben-Michael, Eli, Feller, Avi, Rothstein, Jesse   +2 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multifidelity co-kriging metamodeling based on multivariate data fusion for dynamic fit improvement of injection mechanism in squeeze casting

Alexandria Engineering Journal
To improve the dynamic fit the injection mechanism in a squeeze casting machine, this paper proposes a novel multifidelity co-kriging (MFCK) metamodeling method, which fuses high-fidelity measured data with low-fidelity simulated data and considers data ...
Dongdong You, Zhekai Lin, Fenglei Li, Wenbin Pang   +3 more
doaj   +1 more source