Results 131 to 140 of about 34,600,335 (260)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Introducing an alternative nonlinear model to characterize the growth curve in ostrich
Poultry ScienceBy applying a sinusoidal function (as a trigonometric model), this study aimed to introduce this function into ostrich weight development research, using ostrich growth data from the literature and comparing it with some routinely used growth models such
Navid Ghavi Hossein-Zadeh
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Ianna Journal of Interdisciplinary StudiesBackground: Some previous studies have recently demonstrated the relationship between corporate governance (CG) and financial information transparency (FIT). In Vietnam, FIT strongly influences frontier markets and investor behaviour. However, the board
Truong Thao Nghi, Ngo Nhat Phuong Diem,
doaj
Multi-State Models for Panel Data: The msm Package for R [PDF]
Panel data are observations of a continuous-time process at arbitrary times, for example, visits to a hospital to diagnose disease status. Multi-state models for such data are generally based on the Markov assumption.
Christopher Jackson
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Research in Social Sciences and TechnologyIn secondary schools in Southwest Nigeria, the Fourth Industrial Revolution Chemistry Teachers Effectiveness Scale (4IRCTES) items were evaluated for discrimination item parameter and model-data fit to the underlying construct. In this study, a descriptive survey research design was employed.
openaire +2 more sources
, 2014 Model 2 fit for the Bow Valley elk population from winters of 1985/1986–2010/2011. Population data shown with dots (•), the model fit shown with a line (—), the 95% credibility interval for the model distribution shown with gray band.
Joshua F. Goldberg (543394) +2 more
core +1 more source