Results 151 to 160 of about 4,447,912 (339)

Morphological Data Sets Fit a Common Mechanism Much More Poorly than DNA Sequences and Call Into Question the Mkv Model

, 2018
Pablo A. Goloboff, Michael Pittman, Diego Pol, Xing Xu   +3 more
openalex   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Incorporating wellbeing into general factor models: A more complete mental state?

PLoS ONE
PurposeThis study aimed to understand whether incorporating wellbeing as another dimension within general factor models of mental health is (a) feasible and (b) useful.MethodsData from two time points (Year 7 and Year 9) for 15258 adolescents who ...
Ritika Chokhani, Suzet Tanya Lereya, Jessica Deighton   +2 more
doaj   +1 more source

Hill equation fits of modeled data at a range of cofactor amounts along with the fit to the transcriptional response in Fig 1 in Powis et al. (2011) [61].

, 2015
Ted W. Simon (749287), Robert A. Budinsky (749288), Craig Rowlands J.   +2 more
openalex   +2 more sources

Predictive Coding or Just Feature Discovery? An Alternative Account of Why Language Models Fit Brain Data [PDF]

, 2022
Richard Antonello, Alexander G. Huth
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Common Model-Data Fit Test Statistics in Item Response Theory

Advances in Psychological Science, 2014
Xintong SHAN, Huiye TAN, Yong LIU, Fangwen WU, Dongbo TU   +4 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Risk-adjusted colorectal cancer screening using the FIT and routine screening data: development of a risk prediction model [PDF]

, 2017
Jennifer Cooper, Nick Parsons, Chris Stinton, Christopher Mathews, Steve Smith, Stephen P Halloran, Sue Moss, Sian Taylor‐Phillips   +7 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source