Results 201 to 210 of about 9,651 (256)

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

Cell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi‐Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu, Gang Fan, Juan Peng, Xiaoyan Dai, Zhihan Tang   +13 more
wiley   +1 more source

Topical Astaxanthin Attenuates Imiquimod-Induced Psoriasiform Dermatitis by Downregulating Psoriasis-Associated Keratin Gene Expression (Krt16, Krt17, Krt6a) and Inhibiting the JAK-STAT Signaling Pathway. [PDF]

Molecules
Albahadly WKY, Al-Saedi HFS, Ashoor JA, Rasool MI, Hasan SA, ALtrufi MH.   +5 more
europepmc   +1 more source

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Pioglitazone Attenuates Sepsis-Associated Acute Kidney Injury by Modulating TLR-4/NF-κB Signaling and Improving Survival and Renal Function. [PDF]

J Clin Med
Hacım NA, Akbaş A, Akbaş B, Ercan G, Serdaroglu A, Aygun H, Erbas O.   +6 more
europepmc   +1 more source

Hybrid Computational Modeling with Multi-Level Validation Identifies TK1-VIM as a Robust Therapeutic Pair in Triple-Negative Breast Cancer. [PDF]

Int J Mol Sci
Monteiro SA, Carvalho LAV, Waghabi MC, Silva FABD.   +3 more
europepmc   +1 more source

Quercetin Emulsion Ameliorates UVA-Induced Skin via Modulation of NRF2/NF-κB Signaling Pathways. [PDF]

Pharmaceuticals (Basel)
Guo J, Qian Z, Ji K, Zhou H, Wang X, Lian C, Liu X, Zhang X.   +7 more
europepmc   +1 more source

Developing Mammary Gland Models for Biomedical Applications. [PDF]

Research (Wash D C)
Zhao J, Lin X, Zhang H, Zhao Y.
europepmc   +1 more source

Synergistic Effects of Nutritional Formula on Joint Inflammation Through Modulation of Bone Metabolism in Rats. [PDF]

Nutrients
Wang H, Wang Y, Fan D, Niu Z, Su H, Li A, Kou R, Yue Z, Wu S, Lv H, Ji X, Hu Y, Zhao Y, Wang S.   +13 more
europepmc   +1 more source

Apigenin attenuates obesity-associated hepatic dysfunction and fibrosis in rats: an integrated biochemical, histological, and ex vivo dielectric study. [PDF]

BMC Pharmacol Toxicol
Moussa SA, Aziz S, Abdel-Rahman RF, Elbaset MA, Fayed HM, Shabana ME, Ibrahim FA, Bashandy SAE.   +7 more
europepmc   +1 more source

Model-Driven Architecture with Emphasis on Industrial Applications : 1st European Workshop, MDA-IA 2004, Enschede, the Netherlands, March 17-18 2004, Proceedings

, 2004
van Sinderen, Marten J., Ferreira Pires, Luis   +1 more
openaire   +1 more source