Results 241 to 250 of about 11,397 (304)

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Polyploid Giant Cancer Cells as a Senescence-Linked State in the Tumor Microenvironment. [PDF]

Cancers (Basel)
Dawson MR, Ghosh D.
europepmc   +1 more source

Microbial Oxidative Stress in Food Fermentations: A Comprehensive Review

eFood, Volume 7, Issue 4, August 2026.
Oxidative stress has a dual role in food fermentations: low ROS supports adaptive signaling, whereas excessive ROS causes cellular damage and process inhibition. Managing redox state as a controllable process variable can improve fermentation robustness and final food quality.
Wanrong Hu, Manxi Wu, Hui Xu, Jiebiao Chen, Wen Cai, Han Yang, Hujing Cao, Xinlin Huang, Jinping Cao, Chongde Sun, Yue Wang, Dongliang Li   +11 more
wiley   +1 more source

A Natural Monoterpene, Carvacrol, Mitigates Bisphenol A-Triggered Hepatorenal Oxidative Damage, Pro-Inflammatory Gene Expression, and Histopathological Alterations in Rats. [PDF]

Life (Basel)
Küçükbüğrü N, Acaroz U.
europepmc   +1 more source

A Myocyte‐Enriched Long Non‐Coding RNA NRMLncR Enhances Myogenesis in Mouse

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
We identified a novel myocyte‐enriched, Notch‐repressed myogenic lncRNA, NRMLncR, that is induced by myogenic regulatory factors (MRFs) during myogenic progression in mouse. NRMLncR localizes to cytoplasmic and nuclear compartments, associates with the RNA‐binding protein CUGBP Elav‐like family member 1 (CELF1), and is linked to neighboring gene Tbx1 ...
Yufen Li, Yumei Zhou, Qing Ying Li, Justine Arrington, Zhengzheng Hu, Mostafa F. Abdelhai, Yubo Wang, Junxiao Ren, Yung‐Yu Cheng, Mingyi Xie, W. Andy Tao, Shihuan Kuang, Feng Yue   +12 more
wiley   +1 more source

MODULATING OXIDATIVE STRESS AND INFLAMMATION: SODIUM BUTYRATE'S THERAPEUTIC PROMISE IN EXPERIMENTAL COLITIS. [PDF]

Arq Gastroenterol
Murshed NMF, Swaroopa S, Al-Awadhi SSA, Poonacha SK, D'Souza C, Hosapatna Laxminarayana KP.   +5 more
europepmc   +1 more source

Time‐ and Region‐Specific Effects of Intranasal Insulin on Oxidative Stress Parameters in the Rat Brain

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Intranasal insulin induced time‐dependent heterogeneous oxidative stress–related responses across brain regions, with opposite patterns in the olfactory and respiratory epithelia, while plasma redox parameters were minimally affected. These redox modulations were found associated with insulin signaling markers, including C‐peptide, AMPK activity, and ...
Jelena Osmanovic Barilar, Leonarda Vlahov, Antonia Krsnik, Luka Mihalic, Ana Babic Perhoc, Davor Virag, Jan Homolak, Melita Salkovic‐Petrisic, Ana Knezovic   +8 more
wiley   +1 more source

Heat stress promotes ferroptosis in Jiaji duck myocardium by disrupting iron homeostasis and inducing lipid peroxidation. [PDF]

Poult Sci
Liang Q, Zheng X, Xu T, Liu P, Chen Y, Lin Z, Gu L.   +6 more
europepmc   +1 more source

Secukinumab Mitigates Cisplatin-Induced Nephrotoxicity and Enhances Cisplatin Cytotoxicity in MCF-7 Cells via IL-17A/NF-κB Axis Modulation. [PDF]

Toxics
Alenezi FN, Zaghloul MS, Nader MA, Abdelmageed ME.   +3 more
europepmc   +1 more source