Results 51 to 60 of about 3,656,540 (298)

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

A Data-Driven Framework for the Development of Reliability-Aware Business Process Digital Twins

Technologies
Digital Twin (DT) technologies are increasingly adopted as valuable methods to support the analysis and optimization of Business Processes (BPs). The use of simulation-based techniques in the BPM context is not new.
Paolo Bocciarelli, Manuel Fiorelli, Andrea D’Ambrogio   +2 more
doaj   +1 more source

Dashboard Meta-Model for Knowledge Management in Technological Ecosystem: A Case Study in Healthcare

Proceedings, 2019
Informal caregivers play an important role in healthcare systems in many countries. They have a high impact on reducing care costs related to dependent persons because their support prevents institutionalization.
Andrea Vázquez-Ingelmo, Alicia García-Holgado, Francisco José García-Peñalvo, Roberto Therón   +3 more
doaj   +1 more source

Semantic model-driven development of service-centric software architectures [PDF]

, 2007
Service-oriented architecture (SOA) is a recent architectural paradigm that has received much attention. The prevalent focus on platforms such as Web services, however, needs to be complemented by appropriate software engineering methods.
Barrett, Ronan, Pahl, Claus
core  

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Suitability of Modern Software Development Methodologies for Model Driven Development

Journal of Information and Organizational Sciences, 2009
As an answer to today’s growing challenges in software industry, wide spectrum of new approaches of software development has occurred. One prominent direction is currently most promising software development paradigm called Model Driven Development (MDD).
Ruben Picek
doaj  

Traceability for Model Driven, Software Product Line Engineering [PDF]

, 2008
Traceability is an important challenge for software organizations. This is true for traditional software development and even more so in new approaches that introduce more variety of artefacts such as Model Driven development or Software Product Lines ...
Anquetil, N., Arboleda, H., Galvao Lourenco da Silva, I., Garcia, A., Grammel, B., Noppen, J.A.R., Rashid, A., Shakil Khan, S.   +7 more
core   +5 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

A Tool Support for Model-Driven Development: An Industrial Case Study from a Measurement Domain

Applied Sciences, 2019
End-user programming may utilize Domain-Specific Modeling Languages (DSMLs) to develop applications in the form of models, using only abstractions found in a specific problem domain.
Tomaž Kos, Marjan Mernik, Tomaž Kosar
doaj   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source