Results 151 to 160 of about 19,125,334 (286)

Model-driven engineering for digital twins: a graph model-based patient simulation application. [PDF]

Front Physiol
Trevena W, Zhong X, Lal A, Rovati L, Cubro E, Dong Y, Schulte P, Gajic O.   +7 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

An industrial case study on using language workbench technology for realizing model-driven engineering

, 2014
Model Driven Engineering (MDE) is a proven approach to improve software development processes by automation. However, traditional development of MDE tooling requires a high upfront cost.
Krekola, M., Pareto, Lars,, Christerson, M., Zhu, Xi,, Helander, M., Ehnebom, S., Phung, Cong Chi,   +6 more
core  

PolyGloT-UML: A Gamified Framework for Enhancing UML Learning Paths

Modeling is a key activity in conceptual design and system design, making learning and understanding modeling languages like the Unified Modeling Language (UML) crucial.
Négrier D., Guidolin T., Kienzle J., Gérard S., Fasol L., Bucchiarone A., Schiavo G., Martorella T.   +7 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Model Driven Language Engineering [PDF]

Modeling is a most important exercise in software engineering and development and one of the current practices is object-oriented (OO) modeling. The Object Management Group (OMG) has defined a standard object-oriented modeling language the Unified ...
Patrascoiu, Octavian
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Model-driven engineering for the social enterprise

, 2015
Model-driven engineering for the social ...
John Grundy (13076748)
core