Results 171 to 180 of about 19,125,334 (286)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Model Driven Engineering [PDF]

, 2011
openaire   +2 more sources

Twist degree of freedom activated by pressure-driven interlayer engineering in spiral WS₂. [PDF]

Nat Commun
Ci P, Sun M, Chen Y, Rho Y, Zhao Y, Xin K, Mai Z, Liang S, Wang Z, Wu J, Hong H, Wei Z, Grigoropoulos CP, Liu YY, Tan PH, Wu J.   +15 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Editorial for the Special Issue on Advances in Digital Manufacturing and Nano Fabrication. [PDF]

Micromachines (Basel)
Cheng J, Zhang J, Liu Q.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Concrete strength prediction using domain-driven feature engineering and explainable LightGBM. [PDF]

Sci Rep
Hereiz A, Elsahy M, Hassan K, El-Metwally S.   +3 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Model Driven Architecture and Modeling Driven Software Development

The monography is a proceeding of the papers presented at the 3rd 3rd International Workshop on Model Driven Architecture and Modeling Driven Software Development In conjinction with the 6th International Conference on Evaluation of Novel Approaches to ...
Ņikiforova, Oksana, Osis, Jānis
core  

Artificial intelligence-driven magnetic property prediction and materials discovery for next-generation spintronics. [PDF]

RSC Adv
Elilarassi R, Sivanandakumar D, Nagarajan P, Ilanchezhiyan P, Venkatachalapathy VSK, Velmurugan K.   +5 more
europepmc   +1 more source