Results 111 to 120 of about 6,421,352 (290)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Data-Driven Model-Free Predictive Control for Zero-Sequence Circulating Current Suppression in Parallel NPC Converters

Energies
This paper proposes a data-driven model-free robust predictive control strategy for parallel three-level NPC inverters based on finite control set model predictive control (FCS-MPC), focusing on the zero-sequence circulating current (ZSCC) problem under ...
Lan Cheng, Shiyu Liu, Jianye Rao, Songling Huang, Junjie Chen, Lin Qiu, Yishuang Hu, Youtong Fang   +7 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Model-Free Control for Greenhouse Automation with Hardware-in-the-Loop and Raspberry Pi Implementation

Engineering Proceedings
This paper presents the design, implementation, and experimental validation of a model-free control strategy for greenhouse climate automation. The proposed approach integrates a real-time embedded controller based on a Raspberry Pi within a Cyber ...
Alexis Montalvo, Sebastian Vega, Danilo Chavez, Oscar Camacho   +3 more
doaj   +1 more source

Model-Free Controller Designs for a Magnetic Micromanipulator

Journal of Dynamic Systems, Measurement, and Control, 2020
Abstract An optimal model-free controller and a linear controller are designed and applied to a horizontal magnetic micromanipulator for controlling microparticles in a liquid environment. An input–output relation based model for the magnetic micromanipulator is obtained, verified, and used in the analysis of controllers.
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Power Optimization of Wind Farms Based on Improved Jensen Model and Deep Reinforcement Learning

Zhongguo dianli
The power capture capability of wind farms is constrained by various factors. To maximize the power output of wind farms and address the impacts of wake effects and turbulent wind speeds, this paper proposes a wind farm control scheme based on deep ...
Guanchao WANG, Yuchong HUO, Qun LI, Qiang LI   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Reliance on model-based and model-free control in obesity. [PDF]

Sci Rep, 2020
Janssen LK, Mahner FP, Schlagenhauf F, Deserno L, Horstmann A.   +4 more
europepmc   +1 more source