Towards a New Model of Leadership for the NHS [PDF]
, 2013 This paper was commissioned by the NHS Leadership Academy as a contribution to thinking about the future development of leadership in and around the NHS. It was prepared in collaboration with the Hay Group.
Holti, Richard, Storey, John
core
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Model Aktivitas Praktikum Lapangan Berbasis Ergonomi (Apelerg) Memperbaiki Respon Fisiologis Tubuh, Menurunkan Kelelahan, dan Meningkatkan Kinerja, Dibandingkan dengan Model Lama (Apel), pada Mahasiswa Fmipa Unima [PDF]
, 2009 Aktivitas praktikum lapangan merupakan kegiatan yang dilakukan sebagaiimplementasi kurikulum akademik di Jurusan Fisika FMIPA UNIMA. Sebagaiimplementasi kurikulum tersebut telah dibuat model aktivitas praktikum lapangan (modelAPeL) dan telah digunakan ...
Adiputra, N. (Nyoman) +3 more
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Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Health Promotion Model "Extracurricular" Approach of Reproductive Health Among Early Adolescents [PDF]
, 2018 The behavior to maintenance of reproductive organs, and self-adjustment on changes during puberty become its own problems on early adolescence (10-14 years old).
Hastuti, L. (Lidia) +4 more
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FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
A reverse predictive model towards design automation of microfluidic droplet generators [PDF]
, 2018 This work has been presented in the 10th IWBDA workshop.Droplet-based microfluidic devices in comparison to test tubes can reduce reaction volumes 10^9 times and more due to the encapsulation of reactions in micro-scale droplets [4].
Douglas, Densmore +2 more
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3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells [PDF]
, 2017 Immunotherapy efficacy relies on the crosstalk within the tumor microenvironment between cancer and dendritic cells (DCs) resulting in the induction of a potent and effective antitumor response.
Bentivegna, Enrico +19 more
core +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source