Results 121 to 130 of about 31,255,758 (309)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Unveiling the environmental impact of earthquakes in Europe

Nature Communications
Earthquakes represent a significant but often overlooked environmental burden in the construction sector, driven by post-disaster repairs and reconstruction that generate substantial carbon emissions. Here, we unveil the environmental toll of earthquakes
Martina Caruso, Vitor Silva, Karim Aljawhari, Al Mouayed Bellah Nafeh, Carmine Galasso   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Comparação de custos de tratamentos de controle de plantas daninhas em abacaxizeiro cultivado no Rio Grande do Sul, Brasil

Pesquisa Agropecuária Gaúcha, 2010
Objetivando reduzir custos foi calculada a eficiência agroeconômica (> produtividade < custo) de cinco tratamentos de controle de plantas daninhas em ensaio conduzido de 27/03/05 a 23/02/07 na Fepagro, Maquiné, RS, delineado em blocos casualizados, cinco
Nelson Sebastião Model, Rodrigo Favreto   +1 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Produção de biomassa de plantas daninhas e seu potencial de uso em lavouras de abacaxizeiro no litoral norte do Rio Grande do Sul, Brasil

Pesquisa Agropecuária Gaúcha, 2009
Este trabalho teve como objetivo identificar e quantificar a produção de biomassa de plantas daninhas para melhorar o seu controle e indicar aquelas com potencial de uso em benefício do solo e da cultura do abacaxizeiro.
Nelson Sebastião Model, Rodrigo Favreto   +1 more
doaj  

MODELTEST: testing the model of DNA substitution

Bioinform., 1998
D. Posada, K. Crandall
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Modelling Modelled

, 2004
A model is one of the most fundamental concepts: it is a formal and generalized explanation of a phenomenon. Only with models we can bridge the particulars and predict the unknown. Virtually all our intellectual work turns around finding models, evaluating models, using models. Because models are so pervasive, it makes sense to take a look at modelling
openaire   +1 more source