Results 51 to 60 of about 466,753 (264)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

FedAWR: Aggregation Optimization in Federated Learning with Adaptive Weights and Learning Rates

Future Internet
Federated Learning (FL) enables collaborative model training without sharing raw data, offering a promising solution for privacy-sensitive applications. However, in real-world deployments, significant disparities in client computational capabilities lead
Tong Yao, Jianqi Li, Jianhua Liu
doaj   +1 more source

A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers

mAbs, 2022
The propensity for some monoclonal antibodies (mAbs) to aggregate at physiological and manufacturing pH values can prevent their use as therapeutic molecules or delay time to market.
James T. Heads, Sebastian Kelm, Kerry Tyson, Alastair D. G. Lawson   +3 more
doaj   +1 more source

Modelling Iterative Judgment Aggregation

Proceedings of the AAAI Conference on Artificial Intelligence, 2018
We introduce a formal model of iterative judgment aggregation, enabling the analysis of scenarios in which agents repeatedly update their individual positions on a set of issues, before a final decision is made by applying an aggregation rule to these individual positions.
Terzopoulou, Z., Endriss, U.
openaire   +2 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

A Large-Scale Empirical Study of LLM Orchestration and Ensemble Strategies for Sentiment Analysis in Recommender Systems

Future Internet
This paper presents a comprehensive empirical evaluation comparing meta-model aggregation strategies with traditional ensemble methods and standalone models for sentiment analysis in recommender systems beyond standalone large language model (LLM ...
Konstantinos I. Roumeliotis, Dionisis Margaris, Dimitris Spiliotopoulos, Costas Vassilakis   +3 more
doaj   +1 more source

Flood damage model bias caused by aggregation [PDF]

Proceedings of the International Association of Hydrological Sciences
Flood risk models provide important information for disaster planning through estimating flood damage to exposed assets, such as houses. At large scales, computational constraints or data coarseness leads to the common practice of aggregating asset data ...
S. Bryant, S. Bryant, H. Kreibich, B. Merz, B. Merz   +4 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source