Results 161 to 170 of about 14,251,254 (300)

A Randomized Basket Trial Design for Dose Optimization Based on Bayesian Model Averaging Using Spike-and-Slab Priors. [PDF]

Stat Med
Yimer BB, Takeda K.
europepmc   +1 more source

Bayesian multiregional clinical trials using model averaging. [PDF]

Biostatistics, 2023
Bean NW, Ibrahim JG, Psioda MA.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Population pharmacokinetics of dalbavancin: external validation, model averaging, and implications for precision dosing in prolonged therapy. [PDF]

Antimicrob Agents Chemother
Sayadi H, Gregoire M, Fromage Y, Labriffe M, Maizaud F, Monchaud C, Codde C, Boutoille D, Marquet P, Woillard J-B.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Telemedicine adoption in cardiology: Determinants and predictors identified using Bayesian Model Averaging and Machine Learning. [PDF]

PLOS Digit Health
Petit P, Nübel J, Walter MJ, Butter C, Heinze M, Ignatyev Y, Haase-Fielitz A, Vuillerme N, Muehlensiepen F.   +8 more
europepmc   +1 more source

Forecasting Pathogen Dynamics with Bayesian Model-Averaging: Application to Xylella fastidiosa. [PDF]

Bull Math Biol, 2023
Abboud C, Parent E, Bonnefon O, Soubeyrand S.   +3 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Trans-dimensional Bayesian model averaging for 13C-metabolic flux analysis: evidence-based flux inference under structural model uncertainty. [PDF]

Bioinformatics
Jadebeck JF, Stratmann A, Beyß M, Nöh K.   +3 more
europepmc   +1 more source

Bayesian model averaging for predicting factors associated with length of COVID-19 hospitalization. [PDF]

BMC Med Res Methodol, 2023
Bahrami S, Hajian-Tilaki K, Bayani M, Chehrazi M, Mohamadi-Pirouz Z, Amoozadeh A.   +5 more
europepmc   +1 more source