Results 101 to 110 of about 3,826,655 (285)
Revstat Statistical Journal, 2006 For square contingency tables with ordered categories, this paper proposes some distance subsymmetry models. The one model indicates that the cumulative probability that an observation will fall in row category i or below and column category i + k (k ...
Sadao Tomizawa +2 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Stratified model categories [PDF]
Fundamenta Mathematicae, 2003 A model category in the sense of \textit{D. G. Quillen} [Homotopical Algebra (Lecture Notes in Mathematics 43, Springer, Berlin) (1967; Zbl 0168.20903)] consists of a category together with three classes of maps (weak equivalences, fibrations and cofibrations) which are required to satisfy some axioms reflecting basic properties in homotopy theory of ...
openaire +2 more sources
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Homotopical categories: from model categories to $(\infty,1)$-categories
, 2019 This chapter, written for "Stable categories and structured ring spectra," edited by Andrew J. Blumberg, Teena Gerhardt, and Michael A. Hill, surveys the history of homotopical categories, from Gabriel and Zisman's categories of fractions to Quillen's model categories, through Dwyer and Kan's simplicial localizations and culminating in $(\infty,1 ...
openaire +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Comonadic Coalgebras and Bousfield Localization
, 2018 For a model category, we prove that taking the category of coalgebras over a comonad commutes with left Bousfield localization in a suitable sense. Then we prove a general existence result for left-induced model structure on the category of coalgebras ...
White, David, Yau, Donald
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source