Results 111 to 120 of about 3,826,655 (285)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PERSUASIVE COMPONENT OF THE METAPHORICAL MODEL “NATURE IS ART” IN ECOLOGICAL DISCOURSE: PRAGMA-COGNITIVE ASPECT

Sovremennye Issledovaniâ Socialʹnyh Problem
Background. The article focuses on the issue of persuasive functioning of a metaphorical model ‘Nature is Art’ in ecological discourse. The relevance is due to the necessity of thorough investigation of a persuasive component of ecological discourse ...
Ksenia A. Pavlova
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Multi-class classification of brain tumors using optimized CNN and transfer learning techniques

Scientific Reports
Brain tumors are abnormal cell growths within the brain or central nervous system that disrupt normal brain function and can be life-threatening. Early detection and precise classification of brain tumors are critical for effective treatment and improved
Vatsala Anand, Ajay Khajuria, Rupendra Kumar Pachauri, Vinay Gupta   +3 more
doaj   +1 more source

An Improved Supervised-LDA Text Model and Its Application [PDF]

Jisuanji gongcheng, 2018
Supervised-Latent Dirichlet Distribution Allocation (s-LDA) model cannot handle the multi-label problem and s-LDA model is not correct distribution in the classification model.The Supervised Labled-LDA(sl-LDA) model is proposed by adding a category label
XU Tengteng,HUANG Hengjun
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Multibranch semantic image segmentation model based on edge optimization and category perception.

PLoS ONE
In semantic image segmentation tasks, most methods fail to fully use the characteristics of different scales and levels but rather directly perform upsampling.
Zhuolin Yang, Zhen Cao, Jianfang Cao, Zhiqiang Chen, Cunhe Peng   +4 more
doaj   +1 more source

Homotopy Theory of Labelled Symmetric Precubical Sets

, 2014
This paper is the third paper of a series devoted to higher dimensional transition systems. The preceding paper proved the existence of a left determined model structure on the category of cubical transition systems.
Gaucher, Philippe
core  

Monoidal model categories

, 2007
A monoidal model category is a model category with a compatible closed monoidal structure. Such things abound in nature; simplicial sets and chain complexes of abelian groups are examples. Given a monoidal model category, one can consider monoids and modules over a given monoid. We would like to be able to study the homotopy theory of these monoids and
openaire   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source