Results 191 to 200 of about 3,826,655 (285)

An auxiliary diagnosis model for the pathological classification of cervical cancer based on radiomics biomarkers. [PDF]

Front Genet
Wang M, Cao Y, Zhu M, Zhao P, Zhou Q, Lan H, Liu J, Lei J.   +7 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Disclaimers and Referral Patterns for Medical Advice Across Urgency Levels: Large Language Model Evaluation Study.

J Med Internet Res
Reis F, Agha-Mir-Salim L, Hickstein R, Reis M, Piper SK, Balzer F, Boie SD.   +6 more
europepmc   +1 more source

Faking in High-Stakes Personality Assessments: A Response-Time-Based Latent Response Mixture Modeling Approach. [PDF]

Educ Psychol Meas
Seitz T, Ulitzsch E.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Artificial intelligence-based classification of Spitz tumors. [PDF]

J Pathol Inform
Lucassen RT, Romers M, Ebbelaar CF, Najem AN, Hayes DP, Mooyaart AL, Roshani S, Wynaendts LCD, Stathonikos N, Breimer GE, Jansen AML, Veta M, Blokx WAM.   +12 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Unified Attention-Based Account of Semantic Impairment in Schizophrenia. [PDF]

Schizophr Bull
Yinon N, Haim C, Paz N, Avraham P, Gilad R, Shaul S, Isaac F, Anat M.   +7 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Prediction of First and Multiple Antiretroviral Therapy Interruptions in People Living With HIV: Comparative Survival Analysis Using Cox and Explainable Machine Learning Models. [PDF]

JMIR Med Inform
Salami D, Koech E, Turan JM, Stafford KA, Nyagah LM, Ohakanu S, Ngugi AK, Charurat M.   +7 more
europepmc   +1 more source