Results 211 to 220 of about 3,826,655 (285)

Integrating artificial intelligence and manual curation to enhance bioassay annotations in ChEMBL. [PDF]

J Cheminform
Smit I, Adasme MF, Manners E, Corbett S, Bosc N, Do HM, Leach AR, O'Boyle NM, Zdrazil B.   +8 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Visual and tactile motion cues enhance the categorisation of novel object shapes. [PDF]

Exp Brain Res
Seveso MA, Hirst RJ, O'Dowd A, Camponogara I, Newell FN.   +4 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Differentiating Borderline from Malignant Ovarian-Adnexal Tumours: A Multimodal Predictive Approach Joining Clinical, Analytic, and MRI Parameters. [PDF]

Cancers (Basel)
Cabedo L, Sebastià C, Munmany M, Saco A, Gallardo E, Sáenz de Argandoña O, Peón G, Carrasco JL, Nicolau C.   +8 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

IGMNN: a diagnosis method for vertical root fractures based on an information gated memory neural network. [PDF]

Sci Rep
Wang J, Jin X, Tang R, Zeng Z, Lin Z, Li Y, Chen Y.   +6 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Prediction of Serious Adverse Events Associated With Pediatric Cardiac Catheterizations: External Model Validation of the CRISP Scoring Method. [PDF]

J Soc Cardiovasc Angiogr Interv
Kurita Y, Chaturvedi R, Benson L.
europepmc   +1 more source