Results 81 to 90 of about 1,178,337 (307)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Enhanced Nuclei Segmentation and Classification via Category Descriptors in the SAM Model
BioengineeringSegmenting and classifying nuclei in H&E histopathology images is often limited by the long-tailed distribution of nuclei types. However, the strong generalization ability of image segmentation foundation models like the Segment Anything Model (SAM) can ...
Miguel Luna +2 more
doaj +1 more source
Unnes Journal of Mathematics Education, 2018 The purposes of this research were to find out the mathematical problem solving ability on learning with TAPPS model and to find out how the description of mathematical problem solving ability on TAPPS model in terms of learning style. This mixed methods
Mashuri Mashuri +2 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Several Categories of Large Language Models (LLMs): A Short Survey
, 2023 Saurabh Pahune, Chandrasekharan Manoj
openalex +1 more source
Model categories, pro-categories and functors
, 2023 This thesis consists of five papers. The first three are concerned with various model structures on ind- and pro-categories, while the last two are concerned with the homotopy theory of functors. In Paper I, a general method for constructing simplicial model structures on ind- and pro-categories is described and its basic properties are studied.
openaire +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Revstat Statistical Journal, 2006 For square contingency tables with ordered categories, this paper proposes some distance subsymmetry models. The one model indicates that the cumulative probability that an observation will fall in row category i or below and column category i + k (k ...
Sadao Tomizawa +2 more
doaj +1 more source