Results 61 to 70 of about 1,197,742 (268)

Lazy Probabilistic Model Checking without Determinisation [PDF]

open access: yes, 2015
The bottleneck in the quantitative analysis of Markov chains and Markov decision processes against specifications given in LTL or as some form of nondeterministic B\"uchi automata is the inclusion of a determinisation step of the automaton under ...
Hahn, Ernst Moritz   +4 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Model checking of trusted cryptographic module

open access: yesTongxin xuebao, 2010
The formal security analysis was given for the trusted cryptographic module according to the specification of the trusted cryptographic module using model checking tools. The flaws in the AP protocol were pointed and the solution was given.
CHEN Xiao-feng, FENG Deng-guo
doaj   +2 more sources

Formal Verification of STPA with Model Checking

open access: yesScientific Journal of Gdynia Maritime University, 2023
As technology advances, hardware-centric systems are rapidly moving towards software-centric ones, and their complexity is rapidly increasing. In particular, systems directly related to safety require thorough verification.
Ryeonggu Kwon, Gihwon Kwon
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Model Checking CSL for Markov Population Models [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2014
Markov population models (MPMs) are a widely used modelling formalism in the area of computational biology and related areas. The semantics of a MPM is an infinite-state continuous-time Markov chain.
David Spieler   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Learning Markov Decision Processes for Model Checking [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2012
Constructing an accurate system model for formal model verification can be both resource demanding and time-consuming. To alleviate this shortcoming, algorithms have been proposed for automatically learning system models based on observed system ...
Hua Mao   +5 more
doaj   +1 more source

Graphical and numerical diagnostic tools to assess multiple imputation models by posterior predictive checking

open access: yesHeliyon, 2023
Problem: The congenial of the imputation model is crucial for valid statistical inferences. Hence, it is important to develop methodologies for diagnosing imputation models.
Mingyang Cai   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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