Results 91 to 100 of about 2,267,483 (329)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

RP-KGC: A Knowledge Graph Completion Model Integrating Rule-Based Knowledge for Pretraining and Inference

Big Data Mining and Analytics
The objective of knowledge graph completion is to comprehend the structure and inherent relationships of domain knowledge, thereby providing a valuable foundation for knowledge reasoning and analysis.
Wenying Guo, Shengdong Du, Jie Hu, Fei Teng, Yan Yang, Tianrui Li   +5 more
doaj   +1 more source

Predictive model selection for completion rate in Massive Open Online Courses

Je-LKS: Journal of E-Learning and Knowledge Society, 2019
In this paper we introduce an approach for selecting a linear model to estimate, in a predictive way, the completion rate of massive open online courses (MOOCs). Data are derived from LMS analytics and nominal surveys.
Annamaria De Santis, Katia Sannicandro, Claudia Bellini, Tommaso Minerva   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

DSKG: A Deep Sequential Model for Knowledge Graph Completion [PDF]

, 2018
Lingbing Guo, Qinghe Zhang, Weiyi Ge, Wei Hu, Yuzhong Qu   +4 more
openalex   +1 more source

The Variables that Predict Science Undergraduates’ Timely Degree Completion: a Conceptual Model [PDF]

, 2022
Gerry Rayner, Theo Papakonstantinou
openalex   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

DFedKG: Diffusion-Based Federated Knowledge Graph Completion

Data Science and Engineering
In recent years, the task of knowledge graph completion has attracted significant attention from researchers. In practical scenarios, multi-source knowledge graph completion is quite common.
Chao Zhao, Yurong Cheng, Boyang Li, Yi Yang, Xue Wang   +4 more
doaj   +1 more source

The Persistence Behaviour of Registered Apprentices: Who Continues, Quits, or Completes Programs? [PDF]

We utilize a multinomial probit model and the 2007 National Apprenticeship Survey (NAS) to investigate the persistence behaviour of individuals enrolled in apprenticeship programs.
Laporte, Christine, Mueller, Richard
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