Results 101 to 110 of about 2,277,084 (288)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
DFedKG: Diffusion-Based Federated Knowledge Graph Completion
Data Science and EngineeringIn recent years, the task of knowledge graph completion has attracted significant attention from researchers. In practical scenarios, multi-source knowledge graph completion is quite common.
Chao Zhao +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Model companions of theories with an automorphism
, 1998 For a theory $T$ in $L, T_\sigma$ is the theory of the models of $T$ with an automorphism $\sigma$. If $T$ is an unstable model complete theory without the independence property, then $T_\sigma$ has no model companion.
Kikyo, Hirotaka
core +1 more source
Hyperbolicity and Model-Complete Fields
International Mathematics Research NoticesAbstract We study model-complete fields that avoid a given quasi-project variety $V$. There is a close connection between hyperbolicity of $V$ and the existence of the model companion for the theory of characteristic-zero fields avoiding rational points on $V$.
Szachniewicz, Michał, Ye, Jinhe
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Models of complete theories [PDF]
Bulletin of the American Mathematical Society, 1963 The semantical concepts, such as satisfaction, truth, and model, form the subject matter of a field known as the theory of models. I am going to discuss today several related recent developments in this field. They all lie in one particular area which is indicated by the title and which will be described more fully in a moment.
openaire +2 more sources