Results 241 to 250 of about 11,068 (304)

Studying Phosphoroorganic Modification of Smac‐Mimetics to Boost Selectivity for cIAP1‐BIR3 and Unravel cIAP1/XIAP Molecular Inhibition Mechanisms

Asian Journal of Organic Chemistry, Volume 15, Issue 7, July 2026.
The phosphoroorganic modification of Smac‐mimetics (SMs) drives selectivity for cIAP1‐ over XIAP‐BIR3. The divalent SM 6 partially dimerizes cIAP1, whereas it prefers intramolecular binding in XIAP. In XIAP the phosphoroorganic moiety of the monovalent SM 7 functions as an IBM, thus inhibiting both BIR2 and BIR3. Created in BioRender.
Elisa Fagnani, Paolo Cocomazzi, Waldemar Goldeman, Marcin Sieńczyk, Francesco Bonì, Mona Amini Baghbadorani, Agnieszka Łupicka‐Słowik, Federica Cossu   +7 more
wiley   +1 more source

A Natural Monoterpene, Carvacrol, Mitigates Bisphenol A-Triggered Hepatorenal Oxidative Damage, Pro-Inflammatory Gene Expression, and Histopathological Alterations in Rats. [PDF]

Life (Basel)
Küçükbüğrü N, Acaroz U.
europepmc   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

An agile approach on model-driven architecture (MDA)

, 2005
openaire   +1 more source

Polyploid Giant Cancer Cells as a Senescence-Linked State in the Tumor Microenvironment. [PDF]

Cancers (Basel)
Dawson MR, Ghosh D.
europepmc   +1 more source

Regulation of Endoplasmic Reticulum Stress Suppresses Early Pro‐Tumorigenic Events During N‐Nitrosodiethylamine‐Induced Hepatocarcinogenesis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
Schematic illustration of the effect of BIX in attenuating the initiation stage of hepatocarcinogenesis. BIX pre‐treatment mitigated N‐nitrosodiethylamine‐induced ER stress, DNA damage, and downstream pro‐tumorigenic events during the initiation phase. It preserved DNA repair capacity, reduced inflammation and cellular proliferation, thereby inhibiting
Maya P. Shetty, Smita Hegde, Sanjay Bharati   +2 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 7, July 2026.
Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui, Xiaxia Du, Felix Kwame Amevor, Yaoyao Xia, You Yang, Lingbin Liu   +5 more
wiley   +1 more source

MODULATING OXIDATIVE STRESS AND INFLAMMATION: SODIUM BUTYRATE'S THERAPEUTIC PROMISE IN EXPERIMENTAL COLITIS. [PDF]

Arq Gastroenterol
Murshed NMF, Swaroopa S, Al-Awadhi SSA, Poonacha SK, D'Souza C, Hosapatna Laxminarayana KP.   +5 more
europepmc   +1 more source

A lightweight hybrid transformer approach for hyperspectral imaging-based drought tolerance evaluation in tea plants. [PDF]

Plant Methods
Li Y, Zhang Y, Wang Y, Chen H, Han X, Mao Y, Sun L, Shen J, Ding Z.   +8 more
europepmc   +1 more source

Heat stress promotes ferroptosis in Jiaji duck myocardium by disrupting iron homeostasis and inducing lipid peroxidation. [PDF]

Poult Sci
Liang Q, Zheng X, Xu T, Liu P, Chen Y, Lin Z, Gu L.   +6 more
europepmc   +1 more source