Results 171 to 180 of about 1,785,688 (300)

Research on strategies for enhancing the competency of safety directors in EPC projects empowered by AI. [PDF]

PLoS One
Guan J, Yang ZC, Wang C.
europepmc   +1 more source

User Experience for Model-Driven Engineering: Challenges and Future Directions

ACM/IEEE International Conference on Model Driven Engineering Languages and Systems, 2017
S. Abrahão, Francis Bourdeleau, B. Cheng, Sahar Kokaly, R. Paige, Harald Störrle, J. Whittle   +6 more
semanticscholar   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Review of Progress of AI in Biomimetics: From Biological Patterns to Closed-Loop Discovery. [PDF]

Biomimetics (Basel)
Hu Z, Hong H, Lin T.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A formal framework for dependability and resilience from a software engineering perspective

Open Computer Science, 2011
Guelfi Nicolas
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Artificial intelligence approaches in biological age prediction: current status and challenges. [PDF]

Br J Biomed Sci
Wang G, Ding P, Li Z, Tang Q, Tu L, Jiang T, Zhang L, Su B, Xu J, An H.   +9 more
europepmc   +1 more source

Model-Driven Engineering for Mission-Critical IoT Systems

IEEE Software, 2017
Federico Ciccozzi, I. Crnkovic, D. D. Ruscio, I. Malavolta, Patrizio Pelliccione, Romina Spalazzese   +5 more
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source