Results 161 to 170 of about 19,227,835 (243)

Model Driven Architecture and Modeling Driven Software Development

The monography is a proceeding of the papers presented at the 3rd 3rd International Workshop on Model Driven Architecture and Modeling Driven Software Development In conjinction with the 6th International Conference on Evaluation of Novel Approaches to ...
Ņikiforova, Oksana, Osis, Jānis
core  

The Evolution of Artificial Intelligence in Antibody Design: From Structure-Based Engineering to Generative Models. [PDF]

Antibodies (Basel)
Szataniak I, Packi K.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Twist degree of freedom activated by pressure-driven interlayer engineering in spiral WS₂. [PDF]

Nat Commun
Ci P, Sun M, Chen Y, Rho Y, Zhao Y, Xin K, Mai Z, Liang S, Wang Z, Wu J, Hong H, Wei Z, Grigoropoulos CP, Liu YY, Tan PH, Wu J.   +15 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Concrete strength prediction using domain-driven feature engineering and explainable LightGBM. [PDF]

Sci Rep
Hereiz A, Elsahy M, Hassan K, El-Metwally S.   +3 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Artificial intelligence-driven magnetic property prediction and materials discovery for next-generation spintronics. [PDF]

RSC Adv
Elilarassi R, Sivanandakumar D, Nagarajan P, Ilanchezhiyan P, Venkatachalapathy VSK, Velmurugan K.   +5 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source