Results 161 to 170 of about 388,807 (307)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Advances in Model Driven Software Engineering.
ERCIM News, 2012 Empirical evidence shows that the use of model driven software engineering can result in an up to 10-fold quality improvement and decreased development time. Researchers from Eindhoven University of Technology tested this on a detector control system at CERN. This brings Turing’s vision of software another step closer.
Brand, van den, M.G.J., Groote, J.F.
openaire +2 more sources
Model Driven Architecture and Modeling Driven Software Development
The monography is a proceeding of the papers presented at the 3rd 3rd International Workshop on Model Driven Architecture and Modeling Driven Software Development In conjinction with the 6th International Conference on Evaluation of Novel Approaches to ...
Ņikiforova, Oksana, Osis, Jānis
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Report from MDE practice: An interview-based evaluation of model-driven engineering uses. [PDF]
PLoS OneAlfraihi H, Lano K.
europepmc +1 more source
Towards a Model-Driven Engineering Approach for Developing Embedded Hard Real-Time Software
, 2008 Model-Driven Engineering (MDE) has been advocated as an effective way to deal with today's software complexity. MDE can be seen as an integrative approach combining existing techniques such as Domain-Specific Modeling Languages (DSML) and Transformation ...
Cordeiro, Lucas +4 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source