Results 141 to 150 of about 388,807 (307)
, 2014 Model Driven Engineering (MDE) is a proven approach to improve software development processes by automation. However, traditional development of MDE tooling requires a high upfront cost.
Krekola, M. +6 more
core
PolyGloT-UML: A Gamified Framework for Enhancing UML Learning Paths
Modeling is a key activity in conceptual design and system design, making learning and understanding modeling languages like the Unified Modeling Language (UML) crucial.
Négrier D. +7 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Model Driven Grant Proposal Engineering
, 2014 We demonstrate the application of Model Driven Engineering techniques to support the development of research grant proposals. In particular, we report on using model-to-text transformation and model validation to enhance productivity and consistency in research proposal writing, and present unanticipated opportunities that were revealed after ...
Kolovos, Dimitrios S. +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Design Model Data Exchange Between Concurrent Engineering Facilities by Means of Model Transformation [PDF]
, 2011 The German Aerospace Center (DLR) is developing the software Virtual Satellite for use in their Concurrent Engineering Facility. Throughout the design process of a spacecraft the software supports engineers to store and manage the data and results of ...
Schaus, Volker +2 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Model-driven engineering for the social enterprise
, 2015 Model-driven engineering for the social ...
John Grundy (13076748)
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
, 2014 Designing complex engineering systems, such as an aircraft or an aero-engine, is immensely challenging. Formal Systems Engineering (SE) practices are widely used in the aerospace industry throughout the overall design process to minimise the overall ...
Eres, M.H. +8 more
core +1 more source