Results 41 to 50 of about 313,524 (264)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Collaborative Model-Driven Software Engineering: A Systematic Update

2021 ACM/IEEE 24th International Conference on Model Driven Engineering Languages and Systems (MODELS), 2021
Current software engineering practices rely on highly heterogeneous and distributed teams working in a collaborative setting. Between 2013-2020, the publication output in the field of collaborative Model-Driven Software Engineering (MDSE) has significantly increased.
David, I., Aslam, K., Faridmoayer, S., Malavolta, I., Syriani, E., Lago, P.   +5 more
openaire   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Formal Model-Driven Engineering: Generating Data and Behavioural Components [PDF]

Electronic Proceedings in Theoretical Computer Science, 2012
Model-driven engineering is the automatic production of software artefacts from abstract models of structure and functionality. By targeting a specific class of system, it is possible to automate aspects of the development process, using model ...
Chen-Wei Wang, Jim Davies
doaj   +1 more source

Model-Driven Approaches for Conversational Agents Development: A Systematic Mapping Study

IEEE Access, 2023
Conversational agents are a piece of software widely used nowadays in several domains, such as e-commerce, customer support, education, among others. To build one, proficiency in distinct areas of knowledge is necessary. Moreover, its development demands
Angel Antonio Martinez-Garate, Jose Alfonso Aguilar-Calderon, Carolina Tripp-Barba, Anibal Zaldivar-Colado   +3 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Model Driven Software Engineering of Power Systems Applications: Literature Review and Trends

IEEE Access, 2019
This paper presents a survey on Software Engineering techniques for the power systems area. Our goal is to identify tools and techniques that can improve the life cycle management of customized applications for Energy Management Systems (SCADA/EMS), by ...
Paulo Neis, Marco A. Wehrmeister, Marcos F. Mendes   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Adopting MDE for Specifying and Executing Civilian Missions of Mobile Multi-Robot Systems

IEEE Access, 2016
Robots are meant to replace humans for a broad variety of everyday tasks, such as environmental monitoring or patrolling large public areas for security assurance.
Federico Ciccozzi, Davide Di Ruscio, Ivano Malavolta, Patrizio Pelliccione   +3 more
doaj   +1 more source