Results 101 to 110 of about 3,021,902 (318)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The aim of model evaluation is to learn about the quality of one or more scientific models. Quality may be conceptualized as accurate and comprehensive representation, relevant similarity, fitness-for-purpose, or in some other way. The conception of quality that is adopted carries implications for the practice of model evaluation, including whether it ...
openaire +3 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The evaluation and meta-evaluation design of the Presidio di Qualita di Ateneo (PARQ)
, 2012 The purpose of this paper is to describe the process of quality analysis made at the time of institution of the Presidio di Ateneo per la Qualità (PARQ), a structure for the internal quality control (required by Italian law), established at the ...
NUZZACI, Antonella
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The construction and validation of a usability evaluation survey for mobile learning environments
The advent of mobile technologies in learning context, has been increased the requirements for developing appropriate usability model to align with mobile learning applications.
Nadia Parsazadeh, Rosmah Ali, Mehran Rezaei, Sanaz Zolfaghar Tehrani
core +1 more source
Policy Influence in Scotland: Evaluation of Beyond the Horizon [PDF]
, 2014 This evaluation is presented as part of the Effectiveness Review Series 2013/14, randomly selected for review under the policy influence thematic area. This report documents the findings of a qualitative impact evaluation, carried out in February 2014 to
Burge, Keith +4 more
core
Ex-Ante Business Model Evaluation Methods:: A Proposal of Improvement and Applicability
, 2019 Purpose: The purpose of this paper is to choose the best method for ex ante business model evaluation, improve it and provide a framework to put it into practice. Design/Methodology/Approach: After an in-depth review, we chose the best method for ex ante
Mateu, Jose M. +4 more
core +2 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source