Results 71 to 80 of about 86,749,145 (256)

Alcohol-Related End-Stage Liver Disease and Transplantation: The Debate Continues

, 1994
Liver transplantation has been an acceptable treatment for end-stage liver disease for many years. The greatest number of patients needing transplantation for survival are those suffering from alcohol-related end-stage liver disease. Throughout the years,
Kelso, Lynn A.
core   +1 more source

Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure [PDF]

Clinical and Molecular Hepatology, 2015
Background/AimsHepatitis-B-related acute-on-chronic liver failure has a poor prognosis. However, the advent of potent oral antiviral agents means that some patients can now recover with medical treatment.
Jung Min Ha, Won Sohn, Ju Yeon Cho, Jeung Hui Pyo, Kyu Choi, Dong Hyun Sinn, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Chul Koh, Seung Woon Paik, Byung Chul Yoo, Yong-Han Paik   +12 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Preoperative Nutritional Support in Children with End-Stage Liver-Disease Accepted for Liver-Transplantation - An Approach to Management

, 1990
Pre‐operative nutritional support was studied in 28 children with end‐stage liver disease awaiting orthotopic liver transplantation. Nasogastric supplemental administration of a standard semi‐elemental enteral nutritional formula was compared with a ...
Strong, R, Wilcox, J., Wilcox, J, Shepherd, R. W., Chin, S. E., Strong, R., Shepherd, RW, Cleghorn, GJ, Ong, TH, Cleghorn, G. J., Chin, SE, Patrick, M, Lynch, S, Patrick, M., Ong, T. H., Lynch, S.   +15 more
core   +1 more source

Within-patient temporal variance in MELD score and impact on survival prediction after TIPS creation

Annals of Hepatology, 2013
Background. To assess within-patient temporal variability in Model for End Stage Liver Disease (MELD) scores and impact on outcome prognostication after transjugular intrahepatic portosystemic shunt (TIPS) creation.Material and methods.
Ron C. Gaba, Kruti D. Shah, Patrick M. Couture, Ahmad Parvinian, Jeet Minocha, M. Grace Knuttinen, James T. Bui   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

End-stage liver disease as the only consequence of a mitochondrial respiratory chain deficiency: no contra-indication for liver transplantation

, 2000
The prerequisite for liver transplantation as a therapeutic option for inherited metabolic diseases should be that the enzyme defect, being responsible for the major clinical (hepatic and/or extra-hepatic) abnormalities, is localised in the liver ...
Jong, K.P. de, van Spronsen, FJ, de Jong, KP, Peeters, P.M., Reijngoud, D.J., Bijleveld, CMA, Smit, GPA, Reijngoud, DJ; id_orcid, Schweizer, JJ, Spronsen, D.J. van, Visser, G., Smit, G.P., Schweizer, J.J., Slooff, M.J.H., Peeters, PMJG, Slooff, MJH, Niezen-Koning, K.E., Ruitenbeek, W., Rake, JP, Visser, G, Bijleveld, C.M., Ruitenbeek, W, Niezen-Koning, KE; id_orcid, Niezen-Koning, KE, Reijngoud, DJ, Rake, J.P.   +25 more
core   +1 more source