Results 81 to 90 of about 86,749,145 (256)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The role of mean platelet volume in predicting severity and prognosis of liver cirrhosis in Egyptian patients

The Egyptian Journal of Internal Medicine, 2019
Background and aims Liver cirrhosis is a major public health problem in Egypt due to widespread infection of hepatitis C virus. Mean platelet volume (MPV) is a noninvasive, inexpensive parameter of complete blood count.
Mohamed S Mohamed, Mohamed A.A Bassiony, Ayman F. Elsayed Mohamed   +2 more
doaj   +1 more source

Predicting death in patients with end-stage liver disease: a new model for assessing disease severity

Инновационная медицина Кубани, 2020
Objective. To define possibilities of clinical application of the new original method for estimating failure (death) probability in patients on a liver transplant waiting list.Material and Methods.
V. L. Korobka, M. Yu. Kostrykin, E. S. Pak, R. O. Dabliz, A. M. Shapovalov   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Development of a decision support tool to facilitate primary care management of patients with abnormal liver function tests without clinically apparent liver disease [HTA03/38/02]. Abnormal Liver Function Investigations Evaluation (ALFIE) [PDF]

, 2007
Liver function tests (LFTs) are routinely performed in primary care, and are often the gateway to further invasive and/or expensive investigations.
David McLernon, McLernon, D, Donnan, Peter T, William Rosenberg, Sullivan, FM, Ryder, S, Donnan, PT, Roderick, Paul, Dillon, John F.; id_orcid, Rosenberg, William, McLernon, David, Paul Roderick, Steinke, Douglas, Donnan, Peter T.; id_orcid, Peter T Donnan, Ryder, Stephen, Sullivan, Frank M, Dillon, John F, Rosenberg, W, Frank M Sullivan, Stephen Ryder, Steinke, D, Dillon, JF, Dillon, John F., Sullivan, Frank M., John F Dillon, Douglas Steinke, Donnan, Peter T., Roderick, P, Steinke, Douglas; id_orcid, Roderick Paul, Sullivan Frank M, Dillon John F, Donnan Peter T, McLernon David, Steinke Douglas, Rosenberg William, Ryder Stephen   +37 more
core   +2 more sources

Defining a Liver Transplant Benefit Threshold for the Model for End-Stage Liver Disease-Sodium Score

, 2020
The benefits of transplant are shown as the difference in survival posttransplant versus that shown if the patient had remained on the wait list. Serum sodium was added to improve prediction. We sought to revisit the question of which Model for End-Stage
Black, Sylvester M, Azouley, Daniel, Bagante, Fabio, Pawlik, Timothy M, Akateh, Clifford, Tumin, Dmitry, Beal, Eliza W, Washburn, Kenneth   +7 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source