Results 51 to 60 of about 2,644,305 (305)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Development of a new model to adopt blockchain in public administration

Revista Facultad de Ingeniería Universidad de Antioquia
Blockchain technology is attracting growing attention across various sectors, including public administration, due to attributes such as decentralization, reliability, predictability, network distribution, profiling, and security.
Jhon Wilder Sánchez-Obando, Luis Fernando Castillo-Ossa, Nestor Dario Duque Mendez   +2 more
doaj   +1 more source

Problems of realization of political and administrative reformation of public administration management system

Aspekti Publìčnogo Upravlìnnâ, 2019
Political and administrative reform of the public administration system is the implementation of a set of public administration mechanisms aimed at modernizing and developing the public administration system, optimizing public authorities and local self ...
Yuri Sak
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A comprehensive mechanism of public administration in the field of forensic expertise in Ukraine

Theory and Practice of Public Administration
From the standpoint of the institutional approach, a definition of the concept of “mechanisms of public administration in the field of forensic activity” is proposed.
Nataliia Martynenko
doaj   +1 more source

Recognition of Public Management and Administration Knowledge Identity [PDF]

پژوهش‌های مدیریت عمومی, 2016
Speaking about public administration field’s identity makes researchers confused about variety of some interdisciplinary, multidisciplinary and quasi/sub paradigms concepts.
ali asghar poor ezzat, minasadat Hashemi Kasvaie   +1 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Modern public management in Russia: development of marketing models or return to the administrative–bureaucratic system? [PDF]

, 2016
Статья посвящена проблеме осмысления модели формирования и развития современного государственного управления в России. Раскрывается маркетинговая модель государственного управления, показываются основные ее элементы, сущность и роль в современном ...
Alexandrov, O. G., Александров, О. Г.   +1 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source