Results 191 to 200 of about 1,079,572 (317)

Serum uric acid-to-HDL-C ratio as an independent predictor of metabolic syndrome in the elderly: diagnostic model optimization and inflammatory mechanism insights. [PDF]

BMC Geriatr
Sun R, Hu M, Sun Z, Wang N, Wang J, Wu H, Yang J, Jin Y.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Early Dengue Prediction in Bangladesh: A Comparative Study With Feature Analysis, Explainable Artificial Intelligence, and Model Optimization. [PDF]

J Trop Med
Bhuiyan MA, Akash MRS, Islam R, Polash SI, Khushbu SA.   +4 more
europepmc   +1 more source

Model optimization and performance evaluation of hand cranked music box base structure manufactured via 3D printing. [PDF]

Heliyon, 2021
Alfarisi NAS, Santos GNC, Norcahyo R, Sentanuhady J, Azizah N, Muflikhun MA.   +5 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

A Prediction Model Optimization Critiques through Centroid Clustering by Reducing the Sample Size, Integrating Statistical and Machine Learning Techniques for Wheat Productivity. [PDF]

Scientifica (Cairo), 2022
Islam M, Shehzad F.
europepmc   +1 more source

Comparison of response surface methodology and the Nelder and Mead simplex method for optimization in microsimulation models

Microsimulation models are increasingly used in the evaluation of cancer screening. Latent parameters of such models can be estimated by optimization of the goodness-of-fit.
Neddermeijer, H.G., Piersma, N., Dekker, R., Oortmarssen, G.J. van, Habbema, J.D.F.   +4 more
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Uncertainty evaluation and model optimization in multi-source reservoir modeling. [PDF]

Sci Rep
Ma P, Lin C, Liu H, Li S, Wang S.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source