Results 91 to 100 of about 23,341,870 (343)

Editorial: Insights in methods and model organisms: 2021 [PDF]

, 2022
Stephan C. F. Neuhauss
openalex   +1 more source

Zebrafish (Danio rerio) as a Model Organism

Current Trends in Cancer Management, 2018
Animals as model organisms, the silent sentinels, stand watch over the environmental health of the world. These are non-human animal species which can be used to understand specific biological processes and to obtain informations which can provide an ...
Farmanur Rahman Khan, Saleh Sulaiman Alhewairini   +1 more
semanticscholar   +1 more source

Modelling ? Phase Organic Conductors

Journal de Physique I, 1996
κ-phase organic conductors with bidimensional layers of orthogonal molecular dimers are modelled by tetramers and hexamers of appropriate geometry. The complex conductivity is calculated within the Hubbard model including the electron-intramolecular vibration coupling. The polarized optical conductivity data of two κ-phase charge-transfer salts of bis-(
Yartsev, V., Drozdova, O., Semkin, V., Vlasova, R.   +3 more
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Editorial: Model organisms and experimental models: opportunities and challenges in vascular physiology research [PDF]

, 2023
Víctor M. Pulgar, Christelle Guibert, Al‐Shaimaa F. Ahmed, Aaron J. Trask   +3 more
openalex   +1 more source

Are Model Organisms Theoretical Models? [PDF]

Disputatio, 2017
Abstract This article compares the epistemic roles of theoretical models and model organisms in science, and specifically the role of non-human animal models in biomedicine. Much of the previous literature on this topic shares an assumption that animal models and theoretical models have a broadly similar epistemic role—that of indirect ...
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD

Alzheimer's & Dementia, 2017
Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic biological mechanisms underlying AD, we do not know how to prevent it, nor do we have an approved ...
Adrian L. Oblak, S. Forner, Paul R. Territo, Michael Sasner, G. Carter, G. Howell, Stacey J. Sukoff‐Rizzo, Benjamin A. Logsdon, L. Mangravite, A. Mortazavi, D. Baglietto-Vargas, K. Green, G. MacGregor, M. Wood, A. Tenner, F. LaFerla, B. Lamb   +16 more
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source