Results 111 to 120 of about 957,044 (346)

Diffusion of self-propelled particles in complex media

open access: yes, 2018
The diffusion of active microscopic organisms in complex environments plays an important role in a wide range of biological phenomena from cell colony growth to single organism transport.
Alexander-Katz, Alfredo   +2 more
core   +1 more source

Are Model Organisms Theoretical Models? [PDF]

open access: yesDisputatio, 2017
Abstract This article compares the epistemic roles of theoretical models and model organisms in science, and specifically the role of non-human animal models in biomedicine. Much of the previous literature on this topic shares an assumption that animal models and theoretical models have a broadly similar epistemic role—that of indirect ...
openaire   +2 more sources

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

open access: yesFEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli   +4 more
wiley   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

open access: yesFEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi   +5 more
wiley   +1 more source

Lipid Metabolism and Comparative Genomics [PDF]

open access: yes, 2006
Unilever asked the Study Group to focus on two problems. The first concerned dysregulated lipid metabolism which is a feature of many diseases including metabolic syndrome, obesity and coronary heart disease.
Jones, Janette   +5 more
core  

Most autophagic cell death studies lack evidence of causality

open access: yesFEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

The Influence of a Hospitable Healthcare Environment on Patient Emotions and Behavioral Responses [PDF]

open access: yes, 2018
A structural model is proposed and empirically examined that investigates the influence of a medical center’s environment on patient responses. A stimulus-organism-response (S-O-R) model, often used to frame hospitality service research, is adapted ...
Mody, Makarand, Suess, Courtney
core  

Extremal Coupled Map Lattices

open access: yes, 1999
We propose a model for co-evolving ecosystems that takes into account two levels of description of an organism, for instance genotype and phenotype. Performance at the macroscopic level forces mutations at the microscopic level.
Abramson, Guillermo, Vega, Jose Luis
core   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

open access: yesFEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy