Results 61 to 70 of about 735,742 (300)

Towards the Model Driven Organization [PDF]

2014 47th Hawaii International Conference on System Sciences, 2014
Todays modern organization is faced with a need for rapid response to changes from external business pressures by updating systems and operational procedures. The effect of such continuous evolution eventually leads to sub- optimal configurations of its underlying systems.
Tony Clark 0001, Vinay Kulkarni 0001, Balbir Barn, Robert B. France, Ulrich Frank, Dan Turk   +5 more
openaire   +4 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation

Cancer Medicine, 2019
Accumulating evidence supports the notion that epigenetic modifiers are abnormal in carcinogenesis and have a fundamental role in cancer progression. Among these aberrant epigenetic modifiers, the function of histone methyltransferase KMT2A in somatic ...
Yang Fang, Dan Zhang, Tingting Hu, Hongyan Zhao, Xuan Zhao, Zhefeng Lou, Yongshan He, Wenzheng Qin, Jianfu Xia, Xiaohua Zhang, Le‐chi Ye   +10 more
doaj   +1 more source

Preclinical model of type 1 diabetes and myocardial ischemia/reperfusion injury in conscious rabbits—demonstration of cardioprotection with rapamycin

STAR Protocols, 2021
Summary: We developed a preclinical model of myocardial ischemia/reperfusion (I/R) injury in conscious diabetic rabbits to identify an early pharmacological intervention for patients with diabetes and acute myocardial infarction (AMI).
Arun Samidurai, Ramzi Ockaili, Chad Cain, Sean K. Roh, Scott M. Filippone, Donatas Kraskauskas, Rakesh C. Kukreja, Anindita Das   +7 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Reproductive pair correlations and the clustering of organisms [PDF]

, 2001
Clustering of organisms can be a consequence of social behaviour, or of the response of individuals to chemical and physical cues. Environmental variability can also cause clustering: for example, marine turbulence transports plankton and produces ...
W. R. Young, Young, W. R., Stuhne, Gordan, G. Stuhne, A. J. Roberts, Roberts, A. J.   +5 more
core   +1 more source

A genotype-phenotype screening system using conditionally immortalized immature dendritic cells

STAR Protocols, 2021
Summary: Here, we describe a protocol for CRISPR/Cas9-mediated gene knockout in conditionally immortalized immature dendritic cells (DCs), which can be limitlessly expanded before differentiation. This facilitates the genetic screening of DC functions in
Liwei Zhao, Peng Liu, Wei Xie, Shuai Zhang, Sebastian Thieme, Laurence Zitvogel, Guido Kroemer, Oliver Kepp   +7 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Novel model organisms and proteomics for a better biological understanding [PDF]

The concept of « model organisms » is being revisited in the light of the latest advances in multi-omics technologies that can now capture the full range of molecular events that occur over time, regardless of the organism studied.
Cardon, Tristan, Bertile, Fabrice, Cristobal, Susana, Matallana-Surget, Sabine,, Armengaud, Jean,, Armengaud, Jean, Bertile, Fabrice,, Matallana-Surget, S., Cardon, Tristan,, Matallana-Surget, Sabine, Cristobal, S., Cristobal, Susana,   +11 more
core   +1 more source