Results 61 to 70 of about 14,948,421 (258)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A novel yeast genetic system for determining functions of mammalian proteins through co-cultivation of yeast and mammalian cells

, 2006
1
김준현, 이형진, 송옥규, 장승기, 김정은, 김빛   +5 more
core  

Right Lung Model featuring Upper, Middle and Lower Lobes

, 2020
This is a multi-colored right lung model where each color designates a segment of the upper, middle, and lower lobes.

core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The zebrafish model: a versatile platform for uncovering the therapeutic potential of phytochemicals in liver diseases

Frontiers in Pharmacology
The search for novel therapeutics for prevalent liver diseases such as metabolic dysfunction-associated steatotic liver disease, alcohol-related liver disease, and drug-induced liver injury is constrained by the methodological gaps in conventional ...
Yuliang Liu, Yuliang Liu, Xiang Meng, Xiang Meng, Wei Zhang, Mengmeng Sun, Mengmeng Sun, Ziyoviddin Yusupov, Komiljon Tojibaev, Kobil A. Bobokalonov, Zhenghai Zhang, Min He, Min He, Meiying Jin, Meiying Jin   +14 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Promoting tissue repair with plant-derived compounds: evidence and mechanisms from zebrafish studies

Frontiers in Nutrition
The pursuit of strategies to enhance tissue repair is a central challenge in regenerative medicine, where plant-derived compounds offer immense therapeutic potential due to their multi-target, systems-level activities.
Xiang Meng, Xiang Meng, Xiang Meng, Xuting Song, Xuting Song, Xuting Song, Lixia Zhu, Lixia Zhu, Lixia Zhu, Yiming Wang, Yiming Wang, Yiming Wang, Xianghe Meng, Xianghe Meng, Yufang Tang, Yufang Tang, Kobil A. Bobokalonov, Min He, Min He, Min He, Mengmeng Sun, Mengmeng Sun, Mengmeng Sun, Meiying Jin, Meiying Jin   +24 more
doaj   +1 more source

Sub-series 2: Publications

, 1989
Bimonthly magazine discussing topics related to aviation and model airplane engines including collecting, restoring, maintaining, and identifying engines, along with ...
The Model Museum
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source