Results 121 to 130 of about 6,848,484 (388)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Catapult take off control based on model predictive control

Hangkong gongcheng jinzhan
After separating from the catapult and leaving the flight deck，carrier-based aircraft face multiple constraints including sink rate，angle of attack，and pitch rate to ensure flight safety and quality. Traditional angle-of-attack protection control methods
QIAN Guohong, WEN Zixia, QIU Xin, HUANG Xudong, SHI Ziwei   +4 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Reinforcement learning-based model predictive control for greenhouse climate control

Smart Agricultural Technology
Greenhouse climate control is concerned with maximizing performance in terms of crop yield and resource efficiency. One promising approach is model predictive control (MPC), which leverages a model of the system to optimize the control inputs, while ...
Samuel Mallick, Filippo Airaldi, Azita Dabiri, Congcong Sun, Bart De Schutter   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A configuration of model predictive PID control

Nihon Kikai Gakkai ronbunshu, 2016
Although PID control is still widely used in the industry, it isn't answered a high performance demand. On the other hand, the model predictive control (MPC) is paid attention as effective control but it takes much cost to introduce MPC instead of ...
Ko NAKAMURA, Tohru KAWABE
doaj   +1 more source

Pseudospectral Model Predictive Control under Partially Learned Dynamics

, 2017
Trajectory optimization of a controlled dynamical system is an essential part of autonomy, however many trajectory optimization techniques are limited by the fidelity of the underlying parametric model. In the field of robotics, a lack of model knowledge
Alvarez M. A., Gandhi M., Lázaro-Gredilla M., Pan Y., Rahimi A., Rudin W., Wang J.   +6 more
core   +1 more source

Optimization of the Energy Consumption of Depth Tracking Control Based on Model Predictive Control for Autonomous Underwater Vehicles [PDF]

, 2019
Feng Yao, Yang Chao, Mingjun Zhang, Yujia Wang   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Inverse Model Predictive Control for Power Electronic Converters

IEEE Access
In this paper, a new control technique called inverse model predictive control (IMPC) is proposed for power electronic converters. The proposed IMPC technique is primarily based on the inverse of the conventional finite set model predictive control.
Ali Sharida, Sertac Bayhan, Haitham Abu-Rub, ugur Fesli   +3 more
doaj   +1 more source