Results 131 to 140 of about 7,286,935 (343)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Data-driven nonlinear model reduction to spectral submanifolds in mechanical systems. [PDF]

Philos Trans A Math Phys Eng Sci, 2022
Cenedese M, Axås J, Yang H, Eriten M, Haller G.   +4 more
europepmc   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Balanced truncation for model reduction of biological oscillators. [PDF]

Biol Cybern, 2021
Padoan A, Forni F, Sepulchre R.
europepmc   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Model Reduction Through Progressive Latent Space Pruning in Deep Active Inference. [PDF]

Front Neurorobot, 2022
Wauthier ST, De Boom C, Çatal O, Verbelen T, Dhoedt B.   +4 more
europepmc   +1 more source

Model order reduction of dynamic skeletal muscle models [PDF]

, 2016
Mylena Mordhorst, Daniel Wirtz, Oliver Röhrle   +2 more
openalex   +1 more source

L2 Model Reduction and Variance Reduction

, 1999
In this contribution we demonstrate that estimating a low order model (leaving some dynamics unmodeled) by L2 model reduction of a higher order estimated model may give smaller variance and mean square error than directly estimating it from the same data that produced the high order model.
Tjärnström, Fredrik, Ljung, Lennart
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

HillTau: A fast, compact abstraction for model reduction in biochemical signaling networks. [PDF]

PLoS Comput Biol, 2021
Bhalla US.
europepmc   +1 more source