Results 161 to 170 of about 7,286,935 (343)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Model Studies on Flavin-Dependent Carbonyl-Activation: Reduction of Carbonyl Compounds by Flavohydroquinone [PDF]

, 1972
G. Blankenhorn, Sandro Ghisla, Peter Hemmerich   +2 more
openalex   +1 more source

Model order reduction for delay systems by iterative interpolation [PDF]

, 2020
Dominik Alfke, Lihong Feng, Luigi Lombardi, Giulio Antonini, Peter Benner   +4 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Lyapunov-Global-Lanczos Algorithm for Model Order Reduction & Adaptive PI Controller of Large Scale Electrical Systems

, 2017
Mohamed Kouki, Mehdi Abbes, Abdelkader Mami   +2 more
openalex   +1 more source

Dimension reduction for longitudinal multivariate data by optimizing class separation of projected latent Markov models [PDF]

, 2020
Alessio Farcomeni, Monia Ranalli, Sara Viviani   +2 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Data-Driven Model Reduction for Stochastic Burgers Equations. [PDF]

Entropy (Basel), 2020
Lu F.
europepmc   +1 more source

Reduction of a Cabin Thermal Bond Graph Model [PDF]

, 2018
Youssef Hammadi, David Ryckelynck, Amin El-Bakkali   +2 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source