Results 91 to 100 of about 959,000 (302)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Joint-space adaptive control of a 6 DOF end-effector with closed-kinematic chain mechanism [PDF]
The development is presented for a joint-space adaptive scheme that controls the joint position of a six-degree-of-freedom (DOF) robot end-effector performing fine and precise motion within a very limited workspace.
Nguyen, Charles C., Zhou, Zhen-Lei
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Performance Analysis of Non-linear Jacketed CSTR Based on Different Control Strategies [PDF]
, 2017 This paper aims at finding the optimum controller for a jacketed Continuous Stirred Tank Reactor (CSTR) under non-ideal conditions. Various conventional control methods show poor response for non-linear processes. This paper outlines the design procedure
Barman, J. K. (Jyoti) +1 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Model reference adaptive vector control for induction motor without speed sensor
Advances in Mechanical Engineering, 2017 The wide applications of vector control improve the high-accuracy performance of alternating current (AC) adjustable speed system. In order to obverse the full-order flux and calculate the real-time speed, this article introduces the motor T equivalent ...
Bo Fan +4 more
doaj +1 more source
Adaptive PF (PDF) Speed Control for Servo Drives [PDF]
, 2013 This paper proposes two model reference adaptive PF (PDF) speed control methods for servo drives. Following from the structure (PF‐type) of model reference parameter adaptive control was developed to provide constant loop gain in speed control loop ...
Számel, László
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source