Results 71 to 80 of about 27,507,539 (289)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Research on RBF neural network model reference adaptive control system based on nonlinear U – model

Automatika, 2020
The overall objective of this study is to design the nonlinear U-model-based radial basis function neural network model reference adaptive control system, through research into a class of complex time-varying nonlinear plants.
Fengxia Xu, Shanshan Wang, Furong Liu
doaj   +1 more source

Variable Reference Model for Model Reference Adaptive Control System

IFAC-PapersOnLine, 2015
Abstract In a conventional model reference adaptive control system, a reference model which has desired response characteristics is designed in advance. However, there is a fear that a control output cannot follow a reference model output under the model uncertainty.
T. Shiota, H. Ohmori
openaire   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Model Reference Adaptive Control of Permanent Magnet Synchronous Motor

, 2011
Model Reference Adaptive Control of Permanent Magnet Synchronous MotorIn this paper the classical theory of the direct Model Reference Adaptive Control is used to develop a control algorithm for Permanent Magnet Synchronous Motor (PMSM).
Marián Tárník, Ján Murgaš
core   +1 more source

Advanced pH neutralization control using model reference adaptive control (MRAC) with MIT rule [PDF]

Chemical Industry and Chemical Engineering Quarterly
This study presents the design and implementation of a Model Reference Adaptive Controller (MRAC) using the Massachusetts Institute of Technology (MIT) rule for a pH neutralization process in a continuous reactor.
Hitit Zeynep Yilmazer
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Comparison of architectures and robustness of model reference adaptive controllers and adaptive controllers

, 2014
The paper compares direct and indirect model reference adaptive controllers (MRAC) with the L-1 adaptive controller. The architectures of the closed-loop systems are first compared in a simple setting that clarifies the similarities and differences of ...
Hovakimyan, Naira, Evgeny Kharisov, Kharisov, Evgeny, Naira Hovakimyan, Karl J. Åström, Lund University., Åström, Karl Johan,   +6 more
core   +2 more sources