Results 151 to 160 of about 7,803,855 (292)

Developing a Hospital Disaster Risk Management Evaluation Model

Risk Management and Healthcare Policy, 2019
Masoumeh Abbasabadi Arab,1 Hamid Reza Khankeh,1 Ali Mohammad Mosadeghrad,2 Mehrdad Farrokhi1 1Health in Emergency and Disaster Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; 2Management and Economics School of ...
Abbasabadi Arab M, Khankeh HR, Mosadeghrad AM, Farrokhi M   +3 more
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

High-Risk Clinical Characteristics and Risk Model for Unexpected Cervical Cancer Diagnosed After Surgery in Patients with LSIL/HSIL Biopsy

International Journal of Women's Health
Guilong Pan,1,* Wan Wang,1,* Zhen Sun,1,* Ran Chu,1– 3 Jing Xue,1– 3 Na Li1– 3 1Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China ...
Pan G, Wang W, Sun Z, Chu R, Xue J, Li N
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Laparoscopic cholecystectomy in the Acute Care Surgery model: risk factors for complications. [PDF]

Trauma Surg Acute Care Open, 2019
Fletcher E, Seabold E, Herzing K, Markert R, Gans A, Ekeh AP.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

An examination of process models and model risk frameworks for pharmaceutical manufacturing. [PDF]

Int J Pharm X
O'Connor TF, Chatterjee S, Lam J, Hernán Pérez de la Ossa D, Martinez-Peyrat L, Hoefnagel MHN, Fisher AC.   +6 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Quantile of a Mixture with Application to Model Risk Assessment

Dependence Modeling, 2015
Bernard Carole, Vanduffel Steven
doaj   +1 more source