Results 151 to 160 of about 7,798,376 (295)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Wildfire Risk Zone Mapping in Contrasting Climatic Conditions: An Approach Employing AHP and F-AHP Models [PDF]
, 2023 Aishwarya Sinha +14 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Developing a Hospital Disaster Risk Management Evaluation Model
Risk Management and Healthcare Policy, 2019 Masoumeh Abbasabadi Arab,1 Hamid Reza Khankeh,1 Ali Mohammad Mosadeghrad,2 Mehrdad Farrokhi1 1Health in Emergency and Disaster Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; 2Management and Economics School of ...
Abbasabadi Arab M +3 more
doaj
Impact of Tweet Risks on Global Financial Markets Using the Quantile VAR Model
, 2023 Naeim Shokri
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Laparoscopic cholecystectomy in the Acute Care Surgery model: risk factors for complications. [PDF]
Trauma Surg Acute Care Open, 2019 Fletcher E +5 more
europepmc +1 more source