Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Frontiers in Applied Mathematics and StatisticsMathematical modeling is a powerful method to understand how biological systems work. By creating a mathematical model of a given phenomenon one can investigate which model assumptions are needed to explain the phenomenon and which assumptions can be ...
Vitaly V. Ganusov, Vitaly V. Ganusov
doaj +1 more source
Representative general circulation models selection and downscaling of climate data for the transboundary Koshi river basin in China and Nepal [PDF]
, 2019 Santosh Kaini +4 more
openalex +1 more source
Distributed Channel and Power Level Selection in VANET Based on SINR using Game Model
, 2022 Selo Sulistyo, Sahirul Alam
openalex +2 more sources
Model selection and error estimation [PDF]
We study model selection strategies based on penalized empirical loss minimization. We point out a tight relationship between error estimation and data-based complexity penalization: any good error estimate may be converted into a data-based penalty ...
Gábor Lugosi +2 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin [PDF]
, 2013 Po‐Chang Chiang, Harvey Wong
openalex +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
HABITAT SELECTION MODELS FOR PACIFIC SAND LANCE (AMMODYTES HEXAPTERUS) IN PRINCE WILLIAM SOUND, ALASKA [PDF]
, 2005 William D. Ostrand +3 more
openalex +1 more source