Results 121 to 130 of about 2,501,945 (313)
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
An asymptotic theory for model selection inference in general semiparametric problems. [PDF]
Recently, Hjort and Claeskens (2003) developed an asymptotic theory for model selection, model averaging and post-model selection/averaging inference using likelihood methods in parametric models, along with associated confidence statements.
Claeskens, Gerda, Carroll, RJ
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Metric-Based Model Selection For Time-Series Forecasting [PDF]
Metric-based methods, which use unlabeled data to detect gross differences in behavior away from the training points, have recently been introduced for model selection, often yielding very significant improvements over alternatives (including cross ...
Yoshua Bengio, Nicolas Chapados
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The Properties of Model Selection when Retaining Theory Variables [PDF]
Economic theories are often fitted directly to data to avoid possible model selection biases. We show that embedding a theory model that specifies the correct set of m relevant exogenous variables, x{t}, within the larger set of m+k candidate variables, (
Søren Johansen, David F. Hendry
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Frontiers in Applied Mathematics and StatisticsMathematical modeling is a powerful method to understand how biological systems work. By creating a mathematical model of a given phenomenon one can investigate which model assumptions are needed to explain the phenomenon and which assumptions can be ...
Vitaly V. Ganusov, Vitaly V. Ganusov
doaj +1 more source
Bayesian Averaging, Prediction and Nonnested Model Selection [PDF]
This paper studies the asymptotic relationship between Bayesian model averaging and post-selection frequentist predictors in both nested and nonnested models.
Han Hong, Bruce Preston
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source