Results 131 to 140 of about 1,893,219 (314)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Approach for model-based test specifications in the context of space engineering [PDF]
The increasing complexity and interdisciplinarity of space projects re-quire a formalization and digitalization of the development process. Model-based Systems Engineering offers an approach to formally capture the systems engi-neering methodology and ...
Brahm, Michael +3 more
core
Model of integrative stomatology in neuroinformation space
Эндодонтия Today, 2020 In article basic provisions of model of integrative stomatology are considered. On the basis of the researches conducted by authors regularity of integrative neurostomatosomatologic interactions in neuroinformation space of a human body in normal and ...
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Modeling of the space decay into ”atoms of space”
Mathematical Structures and Modeling, 2020 The article shows how you can mathematically describe the process of decay of space into an infinite number of disconnected pieces that can occur with a complete loss of entanglement parts of the infinitely distant boundary within the 𝐴𝑑𝑆/𝐶𝐹 𝑇-duality.
openaire +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Quintessence phase of the universe in f(Q,T)-gravity with DESI DR2 BAO and Pantheon + SH0ES samples
Nuclear Physics BThis paper investigates the late-time cosmic dynamics using the matter-geometry coupled f(Q,T) gravity model, where Q is the non-metricity scalar and T represents the trace of the energy-momentum tensor.
Shambel Sahlu +4 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
ESTIMATING THE IMPORTANCE OF SHELF SPACE CONFIGURATION ON RETAILER'S PROFIT [PDF]
Retail shelf space allocation remains a central issue in grocery retailing. A literature review produced many studies on retail shelf space allocation, but none which evaluated shelf space allocation using three major factors at once: space, vertical ...
Paul PRECKEL +2 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source