Results 101 to 110 of about 346,476 (312)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Development of an Indoor Space Semantic Model and Its Implementation as an IndoorGML Extension
ISPRS International Journal of Geo-Information, 2019 Geospatial data capture and handling of indoor spaces is increasing over the years and has had a varied history of data sources ranging from architectural and building drawings to indoor data acquisition approaches. While these have been more data format
Nishith Maheshwari +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
SAGE OpenRecreation spaces, as vital components of urban environments, support entertainment, relaxation, and social interaction. As a World Heritage city, Macao faces distinct challenges such as land scarcity, ecological pressures, and traffic congestion.
YaFeng Lai +3 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Connecting physical and virtual spaces in a HyFlex pedagogic model with a focus on teacher interaction [PDF]
, 2019 This article highlights interaction within physical and virtual spaces in a higher education HyFlex learning environment with live streamed lectures and seminars. What kinds of learning spaces do we shape when we connect physical and virtual spaces?
Leijon, Marie, Lundgren, Björn
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Representing functional data in reproducing Kernel Hilbert Spaces with applications to clustering and classification [PDF]
Functional data are difficult to manage for many traditional statistical techniques given their very high (or intrinsically infinite) dimensionality. The reason is that functional data are essentially functions and most algorithms are designed to work ...
Alberto Muñoz, Javier González
core
Claim your space: re-placing spaces to better meet the needs of the net generation [PDF]
, 2008 The challenge for the Reid Library at The University of Western Australia was the transformation of a 1960s building into a welcoming space with services and facilities appropriate for a more technologically demanding generation.
Burke, L., Benn, J., Kiel, R.
core +1 more source